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KMID : 0616120070380010062
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 1 p.62 ~ p.66
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(Effect of Ethanol Extract from Salvia miltiorrhiza on Chemoprevention and Metastasis of Breast Cancer)
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Shon Yun-Hee
Nam Kyung-Soo
Cho Hyun-Jung
Kim Mee-Kyung
Jung Eun-Jung
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Abstract
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Ethanol extract from Salvia miltiorrhiza (SME) was tested for breast cancer chemoprevention and metastasis by measuring the activites of cytochrome P45O 1A1, aromatase, ornithine decarboxylase (ODC), and matrix metalloproteinase (MMP)-9. SME significantly inhibited cytochrome P45O 1A1-mediated ethoxyresorufin O-deethylase (EROD) activity in a dose-dependent manner in a concentration range of 100{sim}l,200 {mu}g/ml (p<0.01). Microsomal aromatase (estrogen synthase) activity was suppressed 54.9%{sim}77.5% by the SME at concentration of 600{sim}l,200 {mu}g/ml. ODC activity induced by 12-O-tet-radecanoylphorbol-13-acetate (TPA) was significantly reduced by the SME 900 and 1,200 {mu}g/ml (p<0.05) in MCF-7 breast cancer cells. In addition, SME (900 and 1,200 {mu}g/ml) markedly inhibited MMP-9 activity, a key role in cancer metastasis. Therefore, SME is worth further investigation with respect to breast cancer chemoprevention or therapy.
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KEYWORD
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Salvia miltiorrhiza, cytochrome P45O 1A1, aromatase, ornithine decarboxylase, matrix metalloproteinase-9
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